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Filtered Search Results
Medchemexpress LLC Melitracen hydrochloride | 10563-70-9 | MFCD00242905 | 99.8% | 327.89 g/mol | C21H26ClN | 1 ML
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Melitracen hydrochloride is a research-grade small molecule antidepressant and anxiolytic agent supplied for in vitro pharmacology, mechanism-of-action studies, and analytical reference. The material is provided with solubility and stock-solution guidance, and recommended storage conditions for both solid and solution forms.
- High purity of 99.8%.
- CAS number 10563-70-9, formula C21H26ClN, molecular weight 327.89 g/mol.
- Available as solid samples and as a pre-made 10 mM solution (1 mL) in DMSO.
- Soluble in DMSO and water at up to 100 mg/mL; ultrasonic assistance may be required.
- Storage: solid at 4°C; in solution store at -80°C up to 6 months or -20°C up to 1 month.
- Includes stock solution preparation guidance for common concentrations.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 500 MG
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SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis. This compound can be used for type 2 diabetes research.
- Inhibits human TXNIP promoter activity and reduces TXNIP mRNA and protein levels in INS-1 cells.
- Lowers glucagon secretion in TC1-6 cells and decreases glucagon secretion and action in vivo.
- Reduces glucagon-induced glucose output from primary hepatocytes and blocks hepatic glucose output in vivo.
- Reverses obesity- and Streptozotocin (STZ)-induced diabetes and hepatic steatosis in mice.
- Orally bioavailable.
- Well-tolerated in male C57BL/6J mice.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Agn 192403 hydrochloride | 1021868-90-5 | 99.0% | 189.73 g/mol | C10H20ClN | 5 MG
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AGN 192403 hydrochloride is the hydrochloride salt of a selective I1-imidazoline receptor antagonist used in cardiovascular and neurological research. It is supplied in small research quantities with high reported purity, and includes solubility and formulation guidance for in vitro and in vivo studies.
- Selective I1-imidazoline receptor antagonist for receptor pharmacology studies.
- Hydrochloride salt form improves solubility in polar solvents.
- High purity suitable for biochemical and cellular assays.
- Available in small milligram quantities for preclinical research.
- Soluble in DMSO; in vivo formulation recipes and concentrations are reported.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Bevantolol hydrochloride | 42864-78-8 | 10 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Bevantolol hydrochloride is a beta-1 and alpha-1 adrenergic receptor antagonist supplied as an analytical standard for laboratory research in adrenergic pharmacology.
- Selective β1 and α1 adrenergic receptor antagonist.
- Supplied as an analytical standard for research use.
- CAS number 42864-78-8.
- Molecular formula C20H28ClNO4; molecular weight 381.89 g/mol.
- Available in small milligram pack sizes, including 10 MG for analytical applications.
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Medchemexpress LLC VU0453379 hydrochloride | 99.0% | 471.03 | 1 ML
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VU0453379 hydrochloride is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R). It exhibits an EC50 of 1.3 μM.
- Highly selective positive allosteric modulator.
- Central nervous system (CNS) penetrant.
- Modulates glucagon-like peptide-1R (GLP-1R).
- Demonstrates an EC50 of 1.3 μM.
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Medchemexpress LLC Alosetron hydrochloride | 122852-69-1 | MFCD03453647 | 99.6% | 10 MG
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Alosetron hydrochloride is a potent, selective 5-HT3 receptor antagonist provided for research use in studies of irritable bowel syndrome and visceral nociception. It is supplied as a high-purity solid and is also available as ready-to-use 10 mM solutions for laboratory assays.
- Potent and selective 5-HT3 receptor antagonist.
- Used in research on diarrhea-predominant irritable bowel syndrome and visceral nociception.
- High purity suitable for analytical and in vitro applications.
- Available as a solid and as pre-made 10 mM solutions for convenience.
- Characterization includes CAS 122852-69-1 and molecular weight 330.81 g/mol.
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Medchemexpress LLC Yonkenafil hydrochloride | 804519-64-0 | 99.4% | 524.08 | C24H34ClN5O4S | 100MG
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Yonkenafil hydrochloride is a phosphodiesterase 5 (PDE5) inhibitor provided as the hydrochloride salt for preclinical research. It has been reported to reduce cerebral infarction and neuronal damage and to modulate neurogenesis, with formulation guidance for both in vitro and in vivo use.
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Medchemexpress LLC Acotiamide hydrochloride | 185104-11-4 | 99.6% | 10 MG
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Acotiamide hydrochloride is a research-grade small molecule and reversible acetylcholinesterase (AChE) inhibitor (IC50 1.79 μM) used to study gastric motility, delayed gastric emptying, and functional dyspepsia. Supplied as the hydrochloride salt with high reported purity for biochemical and pharmacological research.
- Selective, reversible AChE inhibitor with reported IC50 1.79 μM.
- Suitable for studies of gastric motility and functional dyspepsia models.
- Reported high purity (99.62%), appropriate for assay use.
- Storage: sealed at 4°C; in solvent store at -80°C (6 months) or -20°C (1 month).
- Provided in small milligram pack sizes for laboratory research.
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Medchemexpress LLC (S,S,S)-AHPC hydrochloride | 2115897-23-7 | 99.2% | 467.02 | C22H31ClN4O3S | 5MG
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(S,S,S)-AHPC hydrochloride is the hydrochloride salt of an AHPC-derived VHL ligand used as a building block and negative control in E3 ligase recruitment and PROTAC research. It facilitates the study of VHL-mediated ubiquitination and proteasomal degradation, and is supplied for synthetic and assay applications in small research quantities.
- High purity 99.2%
- Molecular weight 467.02
- Chemical formula C22H31ClN4O3S
- Solid white to yellow appearance
- Suitable as a negative control and VHL ligand building block for PROTAC design
- Available in small milligram pack sizes for research use
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Medchemexpress LLC Fendiline (hydrochloride) | 13636-18-5 | 99.8% | 1 ML
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Fendiline hydrochloride is a diphenylalkylamine type of antianginal agent that acts as an L-type calcium channel blocker with an IC50 of 17 μM. It is also identified as a selective K-Ras inhibitor, showing no effect on H-Ras and N-Ras. It inhibits K-Ras plasma membrane localization (IC50 of 9.64 μM) and K-Ras signal output. Additionally, Fendiline hydrochloride is a STING agonist and has demonstrated the ability to inhibit the growth of multiple refractory cold tumors. This product is provided as a 10 mM solution in 1 mL of DMSO with a purity of 99.78%.
- Acts as an L-type calcium channel blocker
- Functions as a selective K-Ras inhibitor
- Inhibits K-Ras plasma membrane localization
- Suppresses K-Ras signal output
- Prevents proliferation of various cancer cell lines
- Serves as a STING agonist
- Inhibits growth of refractory cold tumors
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Medchemexpress LLC Trazodone hydrochloride | 25332-39-2 | 99.6% | 5 G
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Trazodone hydrochloride is a triazolopyridine derivative that acts as a serotonin receptor antagonist and reuptake inhibitor (SARI). It demonstrates anti-depressant and anti-insomnious activity by antagonizing α1- and α2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects. It is suitable for various laboratory applications and research.
- Exhibits anti-depressant and anti-insomnious activity
- Acts as an antagonist against α1- and α2-adrenergic receptors
- Antagonizes histamine H1 receptors
- Demonstrates minimal anticholinergic effects
- Binds to 5-HT1A receptor
- Reduces expression of neuroinflammatory markers
- Increases mRNA expression of BDNF and CREB
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Medchemexpress LLC 9h-Carbazole-3-methanamine, 9-ethyl-N-methyl-, hydrochloride (1:1) | 1050480-30-2 | 99.3% | 274.79 | 1 ML
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PhiKan 083 hydrochloride is a carbazole derivative that binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, and a relative binding affinity (Kd) of 150 μM in Ln229 cells.
- Slows down its thermal denaturation rate.
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Medchemexpress LLC BMY-14802 hydrochloride | 105565-55-7 | 98.0% | 384.85 | 500 UG
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BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. It is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects.
- Selective and orally active sigma receptor antagonist.
- Acts as a 5-HT1A and adrenergic α1 receptor agonist.
- Exhibits antipsychotic effects.
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Medchemexpress LLC SAR407899 hydrochloride | 923262-96-8 | MFCD20485429 | 99.1% | 280.75 g/mol | C14H17ClN2O2 | 10 MG
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SAR407899 hydrochloride is a selective, potent, ATP-competitive inhibitor of Rho-associated kinases (ROCK), supplied as a high-purity solid for preclinical biochemical and cellular research. It is used to probe ROCK-mediated signaling, vascular tone, and smooth muscle responses in vitro and in vivo.
- Selective ATP-competitive ROCK inhibitor with ROCK-2 IC50 ≈135 nM.
- Demonstrates Ki values of 36 nM (human) and 41 nM (rat).
- High purity (99.1%) suitable for research applications.
- Solid, light yellow to khaki appearance; stable when stored sealed at 4°C.
- Applicable to studies of vascular tone, smooth muscle relaxation, and ROCK signaling pathways.
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Medchemexpress LLC Sematilide hydrochloride | 101526-62-9 | MFCD01667315 | 99.3% | 349.88 g·mol⁻1 | C14H24ClN3O3S | 100 MG
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Sematilide hydrochloride is a class III antiarrhythmic research compound that selectively blocks the cardiac IKr (hERG) potassium channel. It inhibits the delayed rectifier K+ current in a concentration-dependent manner (reported IC50 ≈ 25 μM) and is supplied as the hydrochloride salt for in vitro electrophysiology and pharmacology studies. Typical purity is 99.33%.
- Selective IKr (hERG) channel blocker
- Inhibits delayed rectifier K+ current (IC50 ≈ 25 μM)
- Intended for in vitro electrophysiology and pharmacology studies
- High purity suitable for analytical applications
- Available in milligram pack sizes for research use
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